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Ugeskrift for laeger · Oct 2010
Review[Unfractionated heparin and low molecular weight heparin for acute coronary syndromes--assessment of a Cochrane review].
- Steen Elkjaer Husted and Hans Kraemmer Nielsen.
- Medicinsk-kardiologisk Afdeling, Århus Sygehus, Århus Universitetshospital, 8000 Århus C, Denmark. steehust@rm.dk
- Ugeskr. Laeg. 2010 Oct 18; 172 (42): 2888-91.
AbstractIn aspirin-treated patients with acute coronary syndromes without ST-segment elevation unfractionated heparin (UFH) or low molecular weight heparin (LMWH) treatment < 7 days significantly reduce the risk of acute myocardial infarction (AMI), and LMWH furthermore reduces revascularisation. There is a non-significant effect on mortality compared with placebo and an insignificantly increased risk of haemorrhagic complications. No net clinical benefit of LMWH was found compared to UHF, but LMWH has pharmacokinetic advantages. The optimal duration of heparin treatment remains controversial.
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