• Seminars in hematology · Apr 2008

    Review

    Antibody and immunomodulatory agents in the treatment of indolent non-Hodgkin's lymphoma.

    • Ann S LaCasce and Arnold S Freedman.
    • Dana Farber Cancer Institute, Boston, MA 02115-6084, USA. Ann_LaCasce@dfci.harvard.edu
    • Semin. Hematol. 2008 Apr 1; 45 (2): 85-9.

    AbstractImmunomodulatory agents, including cytokines, CpG oligonucleotides, and anti-idiotype vaccines have properties that suggest they have the ability to augment rituximab in the treatment of non-Hodgkin's lymphoma (NHL). Although several clinical trials have shown promising results, no randomized trials of reasonable size have been reported to date, limiting the ability to discern whether combinations of immunomodulatory agents with rituximab impact clinical outcome. Until such trials are mature, we do not recommend using these agents in combination outside of the research setting.

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