• Gan To Kagaku Ryoho · Sep 1992

    Multicenter Study Clinical Trial

    [Evaluation of SN-307 (ondansetron), given intravenously for the treatment of nausea and vomiting caused by anticancer drugs including cisplatin-open study].

    • M Ikeda, T Taguchi, K Ota, H Furue, H Niitani, S Tsukagoshi, Y Ariyoshi, Y Akasaka, J Ohta, and M Suminaga.
    • Department of Obstetrics and Gynecology, Kinki University School of Medicine, Osakasayama, Japan.
    • Gan To Kagaku Ryoho. 1992 Sep 1; 19 (11): 1905-14.

    AbstractThe anti-emetic effect, safety and clinical usefulness of ondansetron for the treatment of nausea and vomiting caused by anticancer drugs including cisplatin, was evaluated by a multi-institutional study in patients with various malignancies. In this study, ondansetron was given intravenously with mainly a single dose of 4 mg to intervene nausea and vomiting. 1. Efficacy ratio of overall effects on nausea and emesis observed for 24 hours after treatment was 69.8%. 2. No side effect was observed. Laboratory tests showed temporary elevation of serum uric acid level in 1 patient in the group given 4 mg. 3. From these results, it seems that ondansetron, given intravenously after initial vomiting, was highly safe and clinically useful anti-emetic for the treatment of nausea and vomiting associated with anti-cancer drugs.

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