• Zhonghua Zhong Liu Za Zhi · Nov 1997

    Multicenter Study Clinical Trial

    [Phase III clinical studies with ondansetron (Qilu) in the prophylaxis of nausea and vomiting induced by non-cisplatin chemotherapy].

    • J Zhou, B Xu, and A Zhou.
    • Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing.
    • Zhonghua Zhong Liu Za Zhi. 1997 Nov 1; 19 (6): 460-2.

    ObjectiveThis study was undertaken to further determine the clinical value of ondansetron (OND, supplied by Qilu Pharmaceutical Company) in the prophylaxis of nausea and vomiting induced by non-cisplatin chemotherapy.MethodsA total of 193 patients were enrolled in the multicenter prospective study and were given treatment of non-cisplatin based chemotherapy. All patients were treated with OND 8 mg i.v. once a day during chemotherapy, followed by OND 4 mg orally twice a day for one day after chemotherapy.ResultsThe effective control rate (0-2 emetic episodes) on the first day was 93.3%. Total control of delayed vomiting (day 2-5) was as high as 94.8 to 99.5%. The mean frequency of vomiting was 0.4, 0.4, 0.2, 0.1 and 0.1, respectively from day 1 to day 5. Adverse effects were minor and tolerable.ConclusionThis modified regimen of treatment with OND is effective in the control of vomiting induced by non-DDP chemotherapy.

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