• Value Health · May 2019

    PROMIS® Adult Health Profiles: Efficient Short-Form Measures of Seven Health Domains.

    • David Cella, Seung W Choi, David M Condon, Ben Schalet, Ron D Hays, Nan E Rothrock, Susan Yount, Karon F Cook, Richard C Gershon, Dagmar Amtmann, Darren A DeWalt, Paul A Pilkonis, Arthur A Stone, Kevin Weinfurt, and Bryce B Reeve.
    • Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Electronic address: d-cella@northwestern.edu.
    • Value Health. 2019 May 1; 22 (5): 537-544.

    BackgroundThere is a need for valid self-report measures of core health-related quality of life (HRQoL) domains.ObjectiveTo derive brief, reliable and valid health profile measures from the Patient Reported Outcomes Measurement Information System® (PROMIS®) item banks.MethodsLiterature review, investigator consensus process, item response theory (IRT) analysis, and expert review of scaling results from multiple PROMIS data sets. We developed 3 profile measures ranging in length from 29 to 57 questions. These profiles assess important HRQoL domains with highly informative subsets of items from respective item banks and yield reliable information across mild-to-severe levels of HRQoL experiences. Each instrument assesses the domains of pain interference, fatigue, depression, anxiety, sleep disturbance, physical function, and social function using 4-, 6-, and 8-item short forms for each domain, and an average pain intensity domain score, using a 0-10 numeric rating scale.ResultsWith few exceptions, all domain short forms within the profile measures were highly reliable across at least 3 standard deviation (30 T-score) units and were strongly correlated with the full bank scores. Construct validity with ratings of general health and quality of life was demonstrated. Information to inform statistical power for clinical and general population samples is also provided.ConclusionsAlthough these profile measures have been used widely, with summary scoring routines published, description of their development, reliability, and initial validity has not been published until this article. Further evaluation of these measures and clinical applications are encouraged.Copyright © 2019 ISPOR–The Professional Society for Health Economics and Outcomes Research. Published by Elsevier Inc. All rights reserved.

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