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- Gholam Hossein Hakimelahi, Kak-Shan Shia, Manijeh Pasdar, Shahram Hakimelahi, Ali Khalafi-Nezhad, Mohammad N Soltani, Nai-Wen Mei, Hui-Ching Mei, Ali A Saboury, Mostafa Rezaei-Tavirani, and Ali A Moosavi-Movahedi.
- Institute of Chemistry, Academia Sinica, Taipei, 115, Taiwan, Republic of China. hosein@tai-genbiotech.com.tw
- Bioorg. Med. Chem. 2002 Sep 1; 10 (9): 2927-32.
AbstractA novel cephalosporin derivative of monohydroguaiaretic acid (cephem-M(3)N, 7) was synthesized and found to possess anticancer activity against human leukemia (K562), breast carcinoma (MCF7), human lung cancer (A549), human colon cancer (Colo205) and pancreatic cancer cells (Capan2 and MiaPaCa2). A tumor targeting fusion protein (dsFv3-beta-lactamase) was also used in conjunction with cephem-based M(3)N 7 and its potency toward K562, MCF7, A549, Colo205, Capan2, and MiaPaCa2 was found to approach that of the free M(3)N (4). In the presence of dsFv3-beta-lactamase, tumor cells were found to be much more susceptible to conjugate 7 than normal human embryonic lung (HEL) cells and normal fibroblasts (Hef522). These notions provide a new approach to the use of nordihydroguaiaretic acid (NDGA) and its derivatives for antitumor therapy.
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