• D Li, J Zheng, and H J Weinmann.
• Department of Radiology, Northwestern University Medical School, 448 E Ontario St, Ste 700, Chicago, IL 60611, USA. d-li2@northwestern.edu
• Radiology. 2001 Mar 1; 218 (3): 670-8.

PurposeTo compare the efficacy of an intravascular contrast agent, gadomer-17, in improving magnetic resonance (MR) imaging of coronary arteries with that of an extravascular agent, gadopentetate dimeglumine, in pigs.Materials And MethodsEight pigs underwent imaging after three injections: 0.20 mmol of gadopentetate dimeglumine per kilogram of body weight and 0.05 and 0.10 mmol/kg gadomer-17. Coronary images were acquired repeatedly after each injection by using an inversion-recovery-prepared segmented three-dimensional sequence with either breath holding (n = 4) or respiratory gating (n = 4). Coronary artery-to-myocardium contrast-to-noise ratios (CNRs) were compared between injections.ResultsAt breath-hold imaging, substantial CNR improvement over precontrast images was observed in images acquired during the first pass of gadopentetate dimeglumine in coronary arteries and up to 6 and 10 minutes after 0.05 and 0.10 mmol/kg of gadomer-17 injections, respectively. The CNR with 0.10 mmol/kg of gadomer-17 was 20% (P <.05) higher than that with gadopentetate dimeglumine at first-pass imaging. At respiratory-gated imaging, significant CNR improvement (P <.05) over precontrast images was observed in images acquired up to 10, 30, and 50 minutes after gadopentetate dimeglumine and both gadomer-17 injections, respectively. The CNR on the first images obtained after 0.10 mmol/kg gadomer-17 injection was 168% (P <.05) higher than that on the images obtained after gadopentetate dimeglumine injection.ConclusionGadomer-17 provided greater and more persistent CNR improvements than did gadopentetate dimeglumine; further evaluation of its utility for coronary imaging in humans is warranted.

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