• Laurence B McCullough, John H Coverdale, and Frank A Chervenak.
• Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, Tex., USA.
• Am. J. Obstet. Gynecol. 2002 Sep 1; 187 (3): 696-702.

ObjectiveBecause there is a dearth of literature, we developed an ethical framework to guide decision making about the management of pregnancy of patients with schizophrenia.Study DesignWe review pertinent literature on schizophrenia and pregnancy, including information on maternal and fetal risks and outcomes, and relate this information to ethical concepts.ResultsThe ethical framework has five components: the concept of chronically and variably impaired autonomy, assisted decision making, surrogate decision making, strategies for dealing with the physician's feelings in response to these patients, and the concept of the fetus as a patient. We apply this ethical framework to clinical challenges of decision making during pregnancy with this patient population.ConclusionsThe preventive ethics strategies of assisted and surrogate decision making can be used to prevent ethical conflicts in decision making about the management of pregnancy of patients with schizophrenia. These preventive ethics strategies should contribute significantly to reducing the vulnerability of these patients and therefore to enhancing their autonomy in the physician-patient relationship.

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