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Zhonghua Wei Chang Wai Ke Za Zhi · Mar 2012
Review[Resistance and treatment strategy of gastrointestinal stromal tumor target therapy].
- Wei Lu and Wei-qi Lu.
- Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China. dr.luwei@fudan.edu.cn
- Zhonghua Wei Chang Wai Ke Za Zhi. 2012 Mar 1; 15 (3): 309-12.
AbstractGastrointestinal stromal tumor(GIST) originates from interstitial cells of Cajal(ICCs). Tyrosine kinase inhibitors(TKI) such as imatinib and sunitinib, are effective agents besides surgery. However some GIST can become primarily or secondarily resistant to those drugs. The difference in gene mutation types and secondary gene mutation is the main cause. When the GIST is proved to be drug resistance, reasonable personal treatment strategies based on individualized medicine should be made to improve outcomes and quality of life.
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