-
Gastroent Hepat Barc · May 2012
[Microalbuminuria and renal insufficiency in chronic hepatitis C virus infection].
- Sami Aoufi Rabih, Rebeca García Agudo, José María Tenías Burillo, Francisco Ruiz Carrillo, Pedro González Carro, Francisco Pérez Roldán, Marina Ynfante Ferrús, Esther Bernardos Martín, Oscar Roncero García... more
- Servicio de Aparato Digestivo, Complejo Hospitalario La Mancha-Centro, Alcázar de San Juan, Ciudad Real, Spain. samiaoufi@hotmail.com
- Gastroent Hepat Barc. 2012 May 1; 35 (5): 309-16.
IntroductionChronic hepatitis C virus (HCV) infection is associated with glomerular disease, which is manifested by proteinuria with or without renal dysfunction.MethodTo determine the prevalence of HCV-associated renal injury and associated risk factors, we performed an observational, analytic, cross-sectional study of 120 HCV-positive patients and 145 HCV-negative controls. Data were gathered from medical records and history-taking and at least three blood and urine analyses were performed over a 1-year period. Renal insufficiency was defined as an estimated glomerular filtration rate of less than 60ml/min/1.73 m2 and/or microalbuminuria of more than 20mg/l or a microalbumin/creatinine ratio higher than 30 mcg/mg.ResultsThe prevalence of microalbuminuria and renal insufficiency was 19.3% and 11.7% in HCV-positive patients versus 10.5% and 0.7% in HCV-negative controls (p 0.04), respectively. A total of 26.1% of HCV-positive patients had signs of renal injury compared with 11.8% of HCV-negative controls (p 0.003). HCV infection was independently and significantly associated with the probability of worsening of renal function. The prevalence of microalbuminuria and renal insufficiency progressively increased with greater age.ConclusionHCV-positive patients show a high prevalence of microalbuminuria and renal insufficiency compared with HCV-negative individuals. The risk of HCV-associated renal insufficiency is independent of the presence of other predisposing factors such hypertension and diabetes.Copyright © 2011 Elsevier España, S.L. and AEEH y AEG. All rights reserved.
Notes
Knowledge, pearl, summary or comment to share?