• Guangfeng Gao, Biyan Gong, and Wen Shen.
• Department of Radiology, The First Central Hospital of Tianjin, Fu'kang Road No. 24, Tianjin 300192, China.
• Surg Oncol. 2013 Sep 1; 22 (3): 195-200.

BackgroundWe performed a meta-analysis to compare the diagnostic performance of integrated (18)FDG PET-CT with that of (18)FDG PET alone and CT alone for the overall assessment of tumor distant metastases.MethodsWe performed a meta-analysis of 11 available articles (1107 patients). We calculated sensitivities, specificities, positive likelihood ratios, and negative likelihood ratios for integrated PET-CT, PET alone, and CT alone, respectively. We also constructed summary receiver operating characteristic curves for integrated PET-CT, PET alone, and CT alone, respectively.ResultsAcross 10 comparative studies (1058 patients), integrated PET-CT has higher sensitivity (0.95 vs 0.85) and similar specificity (0.96 vs 0.95) with PET alone. Across 7 comparative studies (745 patients), integrated PET-CT has higher sensitivity (0.97 vs 0.80) and similar specificity (0.97 vs 0.94) with CT alone.ConclusionIntegrated PET-CT is the most sensitive and accurate modality for tumor distant metastasis staging. Integrating PET with CT may tend to improve the sensitivity than PET alone and CT alone.Copyright © 2013 Elsevier Ltd. All rights reserved.

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