• Psychiat Danub · Nov 2018

    Mozart's music and multidrug-resistant epilepsy: a potential EEG index of therapeutic effectiveness.

    • Chiara Bedetti, Patrizia D'Alessandro, Massimo Piccirilli, Moreno Marchiafava, Antonella Baglioni, Marta Giuglietti, Domenico Frondizi, Marina Menna, and Sandro Elisei.
    • Istituto Serafico di Assisi, Viale Guglielmo Marconi n.6 06081, Assisi, Perugia, Italy, chiarabedetti@serafico.it.
    • Psychiat Danub. 2018 Nov 1; 30 (Suppl 7): 567-571.

    AbstractMultidrug-resistant epilepsy is a pathological condition that affects approximately one-third of patients with epilepsy, especially those with associated intellectual disabilities. Several non-pharmacological interventions have been proposed to improve quality of life of these patients. In particular, Mozart's sonata for two pianos in D major, K448, has been shown to decrease interictal electroencephalography (EEG) discharges and recurrence of clinical seizures in these patients. In a previous study we observed that in institutionalized subjects with severe/profound intellectual disability and drug-resistant epilepsy, a systematic music listening protocol reduced the frequency of seizures in about 50% of cases. This study aims to assess electroencephalography as a quantitative (qEEG) predictive biomarker of effectiveness of listening to music on the frequency of epileptic discharges and on background rhythm frequency (BRF).

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