• Expert Opin Biol Ther · May 2009

    Review

    Re-targeting T-cells against cancer by gene-transfer of tumor-reactive receptors.

    • Victoria Marcu-Malina, Suzanne van Dorp, and Jürgen Kuball.
    • Department of Hematology and VanCreveld Clinic, University Medical Center Utrecht, Utrecht, The Netherlands.
    • Expert Opin Biol Ther. 2009 May 1; 9 (5): 579-91.

    BackgroundAdoptive transfer of T-lymphocytes is a promising treatment for a variety of malignancies, but is often not feasible due to difficulties in generating T-cells reactive with the targeted antigen from patients. To facilitate rapid generation of cells for therapy, T-cells can be programmed with genes encoding for an antigen-specific T-cell receptor (TCR) or chimeric receptors.ObjectiveTo discuss the molecular design and selected pitfalls of TCR gene modified T-cells and T-cells expressing chimeric receptors, so called T-bodies.MethodsA selected review of the recent literature.ConclusionClinical trials report so far only limited efficacy of adoptively transferred genetically modified T-cells. However, the recent progress in engineering tumor-reactive T cells is providing a promising basis to further explore this treatment modality.

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