• WisseLaura E MLEMPenn Image Computing and Science Laboratory, Department of Radiology, University of Pennsylvania, Philadelphia, USA., Ana M Daugherty, Rosanna K Olsen, David Berron, Valerie A Carr, StarkCraig E LCELDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, USA., AmaralRobert S CRSCCerebral Imaging Centre, Douglas Mental Health University Institute, McGill University, Montreal, Canada.Departments of Psychiatry and Biological and Biomedical Engineering, McGill University, Montreal, Canada.Integrated Program in Neur, Katrin Amunts, Jean C Augustinack, Andrew R Bender, Jeffrey D Bernstein, Marina Boccardi, Martina Bocchetta, Alison Burggren, ChakravartyM MallarMMCerebral Imaging Centre, Douglas Mental Health University Institute, McGill University, Montreal, Canada.Departments of Psychiatry and Biological and Biomedical Engineering, McGill University, Montreal, Canada., Marie Chupin, Arne Ekstrom, de FloresRobinRINSERM U1077, Université de Caen Normandie, UMR-S1077, Ecole Pratique des Hautes Etudes, Centre Hospitalier Universitaire de Caen, Caen, France., Ricardo Insausti, Prabesh Kanel, Olga Kedo, Kristen M Kennedy, Geoffrey A Kerchner, Karen F LaRocque, Xiuwen Liu, Anne Maass, Nicolai Malykhin, Susanne G Mueller, Noa Ofen, Daniela J Palombo, Mansi B Parekh, John B Pluta, Jens C Pruessner, Naftali Raz, Karen M Rodrigue, Dorothee Schoemaker, Andrea T Shafer, Trevor A Steve, Nanthia Suthana, Lei Wang, Julie L Winterburn, Michael A Yassa, Paul A Yushkevich, Renaud la Joie, and Hippocampal Subfields Group.
• Penn Image Computing and Science Laboratory, Department of Radiology, University of Pennsylvania, Philadelphia, USA.
• Hippocampus. 2017 Jan 1; 27 (1): 3-11.

AbstractThe advent of high-resolution magnetic resonance imaging (MRI) has enabled in vivo research in a variety of populations and diseases on the structure and function of hippocampal subfields and subdivisions of the parahippocampal gyrus. Because of the many extant and highly discrepant segmentation protocols, comparing results across studies is difficult. To overcome this barrier, the Hippocampal Subfields Group was formed as an international collaboration with the aim of developing a harmonized protocol for manual segmentation of hippocampal and parahippocampal subregions on high-resolution MRI. In this commentary we discuss the goals for this protocol and the associated key challenges involved in its development. These include differences among existing anatomical reference materials, striking the right balance between reliability of measurements and anatomical validity, and the development of a versatile protocol that can be adopted for the study of populations varying in age and health. The commentary outlines these key challenges, as well as the proposed solution of each, with concrete examples from our working plan. Finally, with two examples, we illustrate how the harmonized protocol, once completed, is expected to impact the field by producing measurements that are quantitatively comparable across labs and by facilitating the synthesis of findings across different studies. © 2016 Wiley Periodicals, Inc.© 2016 Wiley Periodicals, Inc.

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