• Int J Mol Sci · Apr 2017

    Review

    Prevention of Colorectal Cancer by Targeting Obesity-Related Disorders and Inflammation.

    • Yohei Shirakami, Masaya Ohnishi, Hiroyasu Sakai, Takuji Tanaka, and Masahito Shimizu.
    • Department of Informative Clinical Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan. ys2443@gifu-u.ac.jp.
    • Int J Mol Sci. 2017 Apr 26; 18 (5).

    AbstractColorectal cancer is a major healthcare concern worldwide. Many experimental and clinical studies have been conducted to date to discover agents that help in the prevention of this disease. Chronic inflammation in colonic mucosa and obesity, and its related metabolic abnormalities, are considered to increase the risk of colorectal cancer. Therefore, treatments targeting these factors might be a promising strategy to prevent the development of colorectal cancer. Among a number of functional foods, various phytochemicals, including tea catechins, which have anti-inflammatory and anti-obesity properties, and medicinal agents that ameliorate metabolic disorders, might also be beneficial in the prevention of colorectal cancer. In this review article, we summarize the strategies for preventing colorectal cancer by targeting obesity-related disorders and inflammation through nutraceutical and pharmaceutical approaches, and discuss the mechanisms of several phytochemicals and medicinal drugs used in basic and clinical research, especially focusing on the effects of green tea catechins.

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