• Support Care Cancer · Sep 2006

    Prognostic factors affecting the outcome of brain metastases from breast cancer.

    • Mu-Tai Liu, Chang-Yao Hsieh, Ai-Yih Wang, Tung-Hao Chang, Chu-Pin Pi, Chia-Chun Huang, Chao-Yuan Huang, and Cheng-Hong Liou.
    • Department of Radiation Oncology, Changhua Christian Hospital, Changhua, Taiwan, Republic of China. 40217@cch.org.tw
    • Support Care Cancer. 2006 Sep 1; 14 (9): 936-42.

    Goals Of WorkThe purpose of this study is to analyze the overall survival rate of patients with brain metastases from breast cancer and to determine prognostic factors affecting outcomes of these patients.Patients And MethodsFrom July 1988 to December 2004, 48 female patients with brain metastases from breast cancer underwent full-dose whole-brain radiotherapy (WBRT). In these patients we evaluated the significance of the following factors in predicting the survival rate after WBRT: age, extracranial metastases, number of brain metastases, total dose of WBRT, Karnofsky performance status (KPS), and Radiation Therapy Oncology Group recursive partitioning analysis (RPA) class.ResultsThe median overall survival rate was 7.3 months. The 1- and 2-year overall survival rates were 37 and 20%, respectively. In univariate analysis, KPS (p<0.0001), number of lesions of brain metastases (p=0.0149), age (p=0.0452), and RPA class (p<0.0001) were statistically significant prognostic factors for overall survival. In multivariate analysis, KPS (p<0.001) and number of brain metastases (p=0.039) were significant prognostic factors for overall survival.ConclusionsSurvival of breast cancer patients with brain metastases treated with WBRT is poor. To improve survival, enrollment of more patients with brain metastases from breast cancer for prospective trials involving a multimodality approach that combines radiation and systemic therapies based on appropriate patient triage is warranted.

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