• Gan To Kagaku Ryoho · Jul 1992

    Multicenter Study Clinical Trial

    [A phase II clinical study of cis-diammine glycolato platinum, 254-S, for advanced breast cancer].

    • H Koyama, M Ogawa, Y Kuraishi, K Tominaga, M Yoshida, and T Taguchi.
    • Department of Surgery, Center for Adult Diseases, Osaka, Japan.
    • Gan To Kagaku Ryoho. 1992 Jul 1; 19 (7): 1049-53.

    AbstractA phase II clinical study of 254-S, a new anticancer platinum complex for advanced breast cancer, was conducted by the 254-S Breast Cancer Study Group consisting of 6 institutions nation-wide. Considering the results of the phase I clinical study, 254-S was administered at 100 mg/m2 by intravenous drip infusion and this administration was repeated at least 2 times at 4-week intervals. Of 19 patients registered, 16 were evaluable for tumor response (complete cases). Partial response (PR) was obtained in 2 patients, for a 12.5% response rate. Major toxic effects observed were hematotoxicity thrombocytopenia and leukopenia, and gastrointestinal toxicity (nausea and vomiting, and anorexia), though there was no case in which the treatment with 254-S had to be discontinued due to the toxic effect.

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