• Tanweer Hasan Khan, Syed Fawad Rizvi, Syed Asaad Mahmood, and Lubna Feroz.
• Dr. Tanweer Hasan Khan, FCPS (Ophth). Consultant Ophthalmologist, LRBT Tertiary Eye Care Hospital, Korangi 2 ½, Karachi, Pakistan.
• Pak J Med Sci. 2021 Jul 1; 37 (4): 979-982.

ObjectiveTo assess the anatomical and functional outcomes of treating chronic persistent large macular hole by macular hole hydrodissection technique in a tertiary eye care hospital.MethodsThis interventional case series study was conducted in the Vitreoretinal department of LRBT Tertiary Teaching Eye Hospital, Karachi, from October 2017 to March 2018, with follow-ups till February 2019. The study included eighteen cases of chronic (symptoms of loss of central vision ≥ 2years), persistent (previously failed macular hole surgery), large (aperture diameter of ≥ 400µm) macular hole. Out of the eighteen patients, eight (44.4%) were males and ten (55.6%) were females. All operated patients underwent macular hole hydrodissection by balanced salt solution using a silicone soft tip extrusion cannula. Patients were followed up post operatively to assess post-operative complications and surgical results.ResultsAmong eighteen patients with a mean aperture diameter of 477.1±102.9 µm and basal diameter of 849.4± 92.6µm, complete anatomical closure was achieved in sixteen (88.8%). Five (27.7%) out of the eighteen patients achieved best corrected visual acuity improvement of 6/36, whereas seven (38.8%) patients reached up to a BCVA of 6/60, with maximum improvement of two lines. The mean post-operative follow-up was 332.3± 46.7 days.ConclusionMacular hole hydrodissection is a relatively new emerging technique with promising results for the closure of chronic persistent large macular hole.Copyright: © Pakistan Journal of Medical Sciences.

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