• Med. Pediatr. Oncol. · Apr 1996

    Case Reports

    All-trans retinoic acid and short-time, high-dose cytarabine in two children with acute promyelocytic leukemia.

    • K Schmitt, A Zoubek, R Schwarz, G Tulzer, E Koller, O Krieger, D Lutz, and H Gadner.
    • Children's Hospital, Vienna, Austria.
    • Med. Pediatr. Oncol. 1996 Apr 1; 26 (4): 254-7.

    AbstractWe report on two girls, 3 and 13 years old, with acute promyelocytic leukemia (APL) who were successfully treated with all-trans retinoic acid (ATRA) 45 mg/m2/day. "Retinoic acid syndrome" was prevented with short-time treatment of high dose (4 x 1.5 g/m2) cytarabine. This regimen was well tolerated, although both children were critically ill. They achieved a complete remission confirmed by light microscopy, but reverse transcriptase polymerase chain reaction remained positive after ATRA, underlining the need of further chemotherapy.

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