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J. Thromb. Haemost. · Jul 2018
Cellular immune responses to platelet factor 4 and heparin complexes in patients with heparin-induced thrombocytopenia.
- I Nazy, R Clare, P Staibano, T E Warkentin, M Larché, J C Moore, J W Smith, R P Whitlock, J G Kelton, and D M Arnold.
- Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.
- J. Thromb. Haemost. 2018 Jul 1; 16 (7): 1402-1412.
AbstractEssentials The immunogenesis of Heparin-induced thrombocytopenia (HIT) is not well understood. Immunization to platelet factor 4 (PF4)-heparin occurs early in life, before any heparin exposure. PF4 and PF4-heparin complexes induce the proliferation of CD14+ cells. Reduced levels of regulatory cytokines contribute to immune dysregulation in HIT.© 2018 International Society on Thrombosis and Haemostasis.
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