• Wai-Tong Ng, Edwin C Y Wong, Alice K W Cheung, James C H Chow, Darren M C Poon, Jessica W Y Lai, Chi-Leung Chiang, Horace C W Choi, Tin-Ching Chau, LeeVictor H FVHFDepartment of Clinical Oncology, Li Ka Shing Faulty of Medicine, The University of Hong Kong, Hong Kong, China., LeeAnne W MAWMDepartment of Clinical Oncology, Li Ka Shing Faulty of Medicine, The University of Hong Kong, Hong Kong, China., Anthony H P Tam, and Kwok-Hung Au.
• Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Hong Kong, China.
• Head Neck. 2019 Oct 1; 41 (10): 3661-3669.

BackgroundThis study evaluates the contemporary care for patients with locally recurrent nasopharyngeal carcinoma after failure of the primary course of intensity modulated radiotherapy.MethodsEligible patients were identified through the Hong Kong Cancer Registry database. Patterns of care and treatment outcomes were analyzed.ResultsTwo hundred seventy-two patients with locally recurrent tumors were identified. Of them, 30.9% received surgery, whereas 35.7% received re-irradiation (re-RT). The 5-year overall survival (OS) for the whole group was 30.2%. Old age and advanced rT classification were adverse prognostic factors, whereas surgery (mainly in resectable recurrence) was associated with favorable survival outcome. The 5-year OS rates for patients who received surgery and re-RT were 56.3% and 21.8%, respectively.ConclusionsEarly detection of resectable recurrence is of paramount importance as surgery for resectable tumors offers the potential to achieve excellent outcomes. Re-RT could be considered in selected patients with unresectable disease and favorable prognostic features.© 2019 Wiley Periodicals, Inc.

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