• Rev Med Chir Soc Med Nat Iasi · Jan 2010

    [Hormone receptors and markers in endometrial hyperplasia. Immunohistochemical study].

    • Alexandra Pungal, Raluca Balan, and C Cotuţiu.
    • Universitatea de Medicină şi Farmacie Gr. T. Popa Iaşi, Facultatea de Medicină, Spitalul Clinic Obstetrică Ginecologie Cuza Vodă Iaşi Clinica I Obstetrică Ginecologie.
    • Rev Med Chir Soc Med Nat Iasi. 2010 Jan 1; 114 (1): 180-4.

    UnlabelledEndometrial hyperplasia is a proliferation of the endometrium with increased number of glands and the change of the gland-stroma ratio. By histopathologic examination is now accepted the WHO classification. Atypical hyperplasia is accepted to be a precursor for endometrioid carcinoma. In order to find some prognostic elements, immunohistochemical reactivity of hormone receptors and markers in endometrial hyperplasia, was performed.Material And MethodsFrom 162 cases of EH, 32 cases were selected for immunohistochemical investigations. Avidin-biotin-peroxidase method was used for revealing estrogen and progesterone receptors (ER, PGR) and Ki-67 and EGF factors.ResultsThe immune reactivity for ER and PGR increase in parallel with the complexity of glandular morphological changes. Ki-67 demonstrated a strong immune reactivity together with EGF in atypical hyperplasias.ConclusionsThe diagnosis of EH can be made by histopathological examinations. The immunohistochemistry aids for the prognosis, in order to establish the best treatment.

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