• Susana Arboleya, Antonio Clemente, Savannah Deng, Marta Bedmar, Isabel Salvador, Patricia Herbera, Vanessa Cunill, Cristòfol Vives-Bauza, Josep Maria Haro, Francesca Canellas, and Maria Rosa Julià.
• Department of Psychiatry, Hospital Universitari Son Espases, Carretera de Valldemossa 79, 07120 Palma de Mallorca, Spain; Faculty of Medicine, Universitat de Barcelona, C/Casanova 143, 08036 Barcelona, Spain. Electronic address: smarboleya@gmail.com.
• Brain Behav. Immun. 2016 Aug 1; 56: 56-60.

AbstractThe role of neuronal surface autoantibodies (NSAs) in non-encephalitic psychosis is of recent and controversial interest. Most of the studies relating NSAs with psychosis are retrospective and only focused on the N-methyl-d-aspartate glutamate receptor (NMDAR). Our goal was to evaluate the prevalence of IgG antibodies against the NMDAR NR1 subunit (NMDAR-Abs) along with five additional NSAs in 61 first psychotic episode patients and 47 matched controls. We found two patients positive for NMDAR-Abs (3.3%). One of them was eventually considered to have been misdiagnosed and reclassified as encephalitis. The other met the criteria for bipolar I disorder, presented no neurological symptoms and had a comorbid HIV infection of vertical transmission. This is the first reported case of an HIV-infected patient with psychosis associated with NSAs. This study shows that patients presenting with clinically incomplete forms of anti-NMDAR encephalitis, with predominant or isolated psychiatric symptoms, can remain undetected if no ancillary tests are performed. To improve patient diagnosis and treatment of individuals with a first psychotic episode, more detailed neurological examinations might be needed. Further studies are required to better clarify the role of NSAs in the neuropsychiatric effects of HIV infection. Copyright © 2016 Elsevier Inc. All rights reserved.

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