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Clin. Pharmacol. Ther. · Aug 2017
ReviewPluripotent Stem Cell-Based Platforms in Cardiac Disease Modeling and Drug Testing.
- N Shaheen, A Shiti, and L Gepstein.
- Rappaport Faculty of Medicine and Research Institute, Haifa, Israel.
- Clin. Pharmacol. Ther. 2017 Aug 1; 102 (2): 203-208.
AbstractThe ability to generate patient/disease-specific human pluripotent stem cell (hPSC)-derived cardiomyocytes (hPSC-CMs) brings a unique value to the fields of cardiac disease modeling, drug testing, drug discovery, and precision medicine. Further integration of emerging innovative technologies such as developmental-biology inspired differentiation into chamber-specific cardiomyocyte subtypes, genome-editing, tissue-engineering, and novel functional phenotyping methodologies should facilitate even more advanced investigations. Here, we review cornerstone concepts and recent highlights of hPSC-based cardiac disease modeling and drug testing.© 2017 American Society for Clinical Pharmacology and Therapeutics.
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