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- Carl Siversson, Jenny Chan, Carl-Johan Tiderius, Tallal Charles Mamisch, Vladimir Jellus, Jonas Svensson, and Young-Jo Kim.
- Department of Medical Radiation Physics, Lund University, Malmö, Sweden. carl.siversson@med.lu.se
- Magn Reson Med. 2012 Jun 1; 67 (6): 1776-81.
AbstractDelayed gadolinium-enhanced MRI of cartilage is a technique for studying the development of osteoarthritis using quantitative T(1) measurements. Three-dimensional variable flip angle is a promising method for performing such measurements rapidly, by using two successive spoiled gradient echo sequences with different excitation pulse flip angles. However, the three-dimensional variable flip angle method is very sensitive to inhomogeneities in the transmitted B(1) field in vivo. In this study, a method for correcting for such inhomogeneities, using an additional B(1) mapping spin-echo sequence, was evaluated. Phantom studies concluded that three-dimensional variable flip angle with B(1) correction calculates accurate T(1) values also in areas with high B(1) deviation. Retrospective analysis of in vivo hip delayed gadolinium-enhanced MRI of cartilage data from 40 subjects showed the difference between three-dimensional variable flip angle with and without B(1) correction to be generally two to three times higher at 3 T than at 1.5 T. In conclusion, the B(1) variations should always be taken into account, both at 1.5 T and at 3 T.Copyright © 2011 Wiley-Liss, Inc.
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