• Am J Dermatopathol · Feb 2013

    Case Reports

    Nonuremic calciphylaxis associated with histologic changes of pseudoxanthoma elasticum.

    • Kristen H Fernandez, Vincent Liu, and Brian L Swick.
    • Department of Dermatology, University of Missouri, Columbia, MO 65212, USA. kristen.1h.fernandez@gmail.com
    • Am J Dermatopathol. 2013 Feb 1; 35 (1): 106-8.

    AbstractCalciphylaxis is a rare condition characterized by medial calcification of small- and medium-sized vessels that subsequently leads to ischemic necrosis. Calciphylaxis most often occurs in patients with end-stage renal disease and secondary hyperparathyroidism. We present a unique case of calciphylaxis in which the patient did not have end-stage renal disease. Instead, primary hyperparathyroidism and/or alcoholic cirrhosis were the more likely causes of her calciphylaxis. In addition, our case demonstrated not only calciphylaxis but also fragmentation and calcification of elastic fibers within the dermis, changes that are most often seen in pseudoxanthoma elasticum. This is the first reported case of calciphylaxis, to our knowledge, with histopathologic changes of pseudoxanthoma elasticum in a patient who is nonuremic.

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