• Omayma O Abdelaleem, Nermeen A Fouad, Olfat G Shaker, Tarek I Ahmed, Noha K Abdelghaffar, Hanaa M Eid, Abdelrahmaan A Mohamed, ElebiaryAhmed MagdyAMDepartment of Medical physiology, Faculty of Medicine, Fayoum University, Fayoum, Egypt., Mohamed M Mohamed, and Rania H Mahmoud.
• Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
• Int. J. Clin. Pract. 2021 Nov 1; 75 (11): e14651.

BackgroundRheumatoid arthritis (RA) is an inflammatory autoimmune disease which affects various tissues and organs mainly joints. Serum microRNAs are considered a new class of non-coding RNA which plays a vital role in pathogenesis of RA.MethodsThe current study was conducted on 80 RA patients and 80 healthy participants. Serum expression levels of miR-224, miR-760, miR-483-5p, miR-378 and miR-375 were evaluated via real-time quantitative polymerase chain reaction (PCR).ResultsSignificant upregulation of miR-224, miR-760, miR-483-5p, miR-378 and miR-375 was reported in the present study with respect to the control group (P = .031, P = .017, P = .026, P = .036 and P = .05, respectively). Furthermore, significant positive correlation between the abovementioned microRNAs with DAS28 score (P < .001, each) was demonstrated.ConclusionEarly detection of RA could be achieved through evaluation of serum expression of miR-224, miR-760, miR-483-5p, miR-378 and miR-375 which also may be used as targets for treatment of patients with RA.© 2021 John Wiley & Sons Ltd.

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