• Nedim Turan, Mustafa Benekli, Dogan Koca, Basak Oven Ustaalioglu, Faysal Dane, Nuriye Ozdemir, Arife Ulas, Ilhan Oztop, Mahmut Gumus, Mehmet Akif Ozturk, Veli Berk, Mehmet Kucukoner, Aytug Uner, Ozan Balakan, Kaan Helvaci, Secil Ozkan, Ugur Yilmaz, Suleyman Buyukberber, and Anatolian Society of Medical Oncology.
• Department of Medical Oncology, Gazi University Faculty of Medicine, Ankara, Turkey. turan.nedim@hotmail.com
• Oncology. 2013 Jan 1; 84 (1): 14-21.

BackgroundWe aimed to investigate the impact of adjuvant systemic therapy with modern chemotherapy combinations on survival outcomes in patients with resected liver-confined metastases from colorectal carcinomas, and whether addition of bevacizumab (BEV) provides further benefit.MethodsA total of 229 consecutive patients who underwent resection for liver-confined colorectal liver metastases were retrospectively analyzed.ResultsOf 229 patients, 204 who received chemotherapy with fluoropyrimidine-based (n = 27), irinotecan-based (n = 84) and oxaliplatin-based (n = 93) combinations were analyzed. Among these, 87 patients received BEV while 117 did not (NoBEV). With a median follow-up of 27 months after metastasectomy, the median recurrence-free survival (RFS) and overall survival (OS) were 17 and 53 months, respectively. OS rates at 3 and 5 years were 71% and 40%, respectively. No significant differences were found in the median RFS (p = 0.744) and OS (p = 0.440) among different chemotherapy regimens. The median RFS (p = 0.375) and OS (p = 0.251) were similar in BEV and NoBEV arms. In multivariate analysis, having 4 liver metastases was the only negative independent factor on both RFS and OS, while positive surgical margin was another negative independent factor for RFS.ConclusionChemotherapy type and addition of BEV have no impact on both RFS and OS in the adjuvant setting following complete resection of colorectal liver metastases.Copyright © 2012 S. Karger AG, Basel.

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