• Birgit Skoffer, Ulrik Dalgas, Thomas Maribo, Kjeld Søballe, and Inger Mechlenburg.
• Department of Physical and Occupational Therapy, Aarhus University Hospital, Nørrebrogade 44, 8000 Aarhus C, Denmark; Institute of Clinical Medicine, Aarhus University, Denmark.
• PM R. 2018 Jul 1; 10 (7): 687-692.

BackgroundPreoperative progressive resistance training (PRT) is controversial in patients scheduled for total knee arthroplasty (TKA), because of the concern that it may exacerbate knee joint pain and effusion.ObjectiveTo examine whether preoperative PRT initiated 5 weeks prior to TKA would exacerbate pain and knee effusion, and would allow a progressively increased training load throughout the training period that would subsequently increase muscle strength.DesignSecondary analyses from a randomized controlled trial (NCT01647243).SettingUniversity Hospital and a Regional Hospital.PatientsA total of 30 patients who were scheduled for TKA due to osteoarthritis and assigned as the intervention group.MethodsPatients underwent unilateral PRT (3 sessions per week). Exercise loading was 12 repetitions maximum (RM) with progression toward 8 RM. The training program consisted of 6 exercises performed unilaterally.Main Outcome MeasuresBefore and after each training session, knee joint pain was rated on an 11-point scale, effusion was assessed by measuring the knee joint circumference, and training load was recorded. The first and last training sessions were initiated by 1 RM testing of unilateral leg press, unilateral knee extension, and unilateral knee flexion.ResultsThe median pain change score from before to after each training session was 0 at all training sessions. The average increase in knee joint effusion across the 12 training sessions was a mean 0.16 cm ± 0.23 cm. No consistent increase in knee joint effusion after training sessions during the training period was found (P = .21). Training load generally increased, and maximal muscle strength improved as follows: unilateral leg press: 18% ± 30% (P = .03); unilateral knee extension: 81% ± 156% (P < .001); and unilateral knee flexion: 53% ± 57% (P < .001).ConclusionPRT of the affected leg initiated shortly before TKA does not exacerbate knee joint pain and effusion, despite a substantial progression in loading and increased muscle strength. Concerns for side effects such as pain and effusion after PRT seem unfounded.Level Of EvidenceI.Copyright © 2018. Published by Elsevier Inc.

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