[Prenatal corticosteroids: short-term and long-term effects

J Gynecol Obstet Biol Reprod (Paris) · Mar 2014

Review

[Prenatal corticosteroids: short-term and long-term effects of multiple courses. Literature review in 2013].

Prenatal corticosteroids administration is one of the major advances in obstetrics and neonatology for the prevention of preterm-birth related complications. However, concerns have been raised about its safety regarding neonatal growth and children development. ⋯ It remains some uncertainty regarding the choice of antenatal corticosteroids, the interval between injections, the timing of effectiveness and the maximum number of courses per pregnancy that is acceptable without causing complications among children. Thus, we performed a current literature review in 2013 regarding short- and long-term efficacy and safety in order to give clear recommendations to practitioners.

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- F Fuchs, F Audibert, and M-V Senat.
- Departement de gynécologie-obstétrique, CHU Sainte-Justine, Montréal, Québec, Canada; Inserm, CESP centre for research in epidemiology and population health, U1018, reproduction and child development, 94807 Villejuif, France; UMRS 1018, université Paris-Sud, 94807 Villejuif, France. Electronic address: florentfuchs@yahoo.fr.
- J Gynecol Obstet Biol Reprod (Paris). 2014 Mar 1; 43 (3): 211-7.
AbstractPrenatal corticosteroids administration is one of the major advances in obstetrics and neonatology for the prevention of preterm-birth related complications. However, concerns have been raised about its safety regarding neonatal growth and children development. Therefore, some obstetricians have restricted the use of corticosteroids to precisely defined indications. It remains some uncertainty regarding the choice of antenatal corticosteroids, the interval between injections, the timing of effectiveness and the maximum number of courses per pregnancy that is acceptable without causing complications among children. Thus, we performed a current literature review in 2013 regarding short- and long-term efficacy and safety in order to give clear recommendations to practitioners. Copyright © 2014. Published by Elsevier Masson SAS.

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