• Fiona M Clement, Scott Klarenbach, Marcello Tonelli, Natasha Wiebe, Brenda Hemmelgarn, and Braden J Manns.
• Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada. braden.manns@albertahealthservices.ca
• Am. J. Kidney Dis. 2010 Dec 1; 56 (6): 1050-61.

BackgroundThe objective was to determine the cost-effectiveness of treating anemic patients with chronic kidney disease (CKD) with erythropoiesis-stimulating agents (ESAs) to a low (9-10.9 g/dL), intermediate (11-12 g/dL), or high (> 12 g/dL) hemoglobin level target compared with a strategy of managing anemia without ESAs.Study DesignCost-utility analysis.Setting & ParticipantsPublicly funded health care system. Anemic patients with CKD, overall and stratified into dialysis-/non-dialysis-dependent subgroups.Model, Perspective, & TimeframeDecision analysis, health care payer, patient's lifetime.Main OutcomeCost per quality-adjusted life-year (QALY) gained.ResultsFor dialysis patients, compared with anemia management without ESAs, using ESAs to target a low hemoglobin level is associated with a cost per QALY of $96,270. Given a lack of direct trials comparing low and intermediate targets, significant uncertainty exists between these strategies. Treatment to a high hemoglobin target was always associated with worse clinical outcomes and higher costs compared with a low hemoglobin target. Results were similar in non-dialysis-dependent patients with CKD, with a cost per QALY for a low target compared with no ESA of $147,980.LimitationsGiven limitations in the available randomized controlled trials, we were able to model only 4 treatment strategies, balancing the need to consider relevant targets with the requirement for accurate estimates of clinical effect. We assumed that the efficacy of the different strategies would continue over a patient's lifetime.ConclusionsUsing ESAs to target a hemoglobin level > 12 g/dL is associated with worse clinical outcomes and significant additional cost compared with using ESAs to target lower hemoglobin levels (9-12 g/dL). Given a lack of studies comparing low (9-10.9 g/dL) and intermediate (11-12 g/dL) hemoglobin targets for clinical outcomes, including quality of life, the most cost-effective hemoglobin level target within the range of 9-12 g/dL is uncertain, although aiming for higher targets within this range will lead to higher costs.Copyright © 2010 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

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