• European cardiology · Feb 2020

    Review

    Myocardial and Microvascular Injury Due to Coronavirus Disease 2019.

    • Rocco A Montone, Giulia Iannaccone, Maria Chiara Meucci, Filippo Gurgoglione, and Giampaolo Niccoli.
    • Department of Cardiovascular Sciences, Fondazione Policlinico Universitario A Gemelli IRCCS Rome, Italy.
    • Eur Cardiol. 2020 Feb 1; 15: e52.

    AbstractOver the past few months, health systems worldwide have been put to the test with the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Even though the leading clinical manifestations of the SARS-CoV-2 infection involve the respiratory tract, there is a non-negligible risk of systemic involvement leading to the onset of multi-organ failure with fatal consequences. Since the onset of COVID-19, patients with underlying cardiovascular disease have been at increased risk of poor clinical outcomes with higher death rates. Moreover, the occurrence of new-onset cardiac complications is not uncommon among patients hospitalised for COVID-19. Of importance, a significant portion of COVID-19 patients present with myocardial injury. Herein, the authors discuss the mechanisms leading to myocardial and microvascular injury in SARS-CoV-2 infection and their clinical implications.Copyright © 2020, Radcliffe Cardiology.

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