• Blood purification · Jan 2011

    Clinical Trial

    Evaluation of a new polysulfone hemofilter for continuous renal replacement therapy.

    • Matteo Floris, Nicola Marchionna, Anna Clementi, Jeong Chul Kim, Dinna N Cruz, Federico Nalesso, Monica Zanella, Francesco Garzotto, Massimo de Cal, Grazia Maria Virzì, Alessandra Brendolan, and Claudio Ronco.
    • Department of Nephrology San Bortolo Hospital and International Renal Research Institute Vicenza, Vicenza, Italy.
    • Blood Purif. 2011 Jan 1; 32 (2): 133-8.

    AbstractNew strategies using continuous renal replacement therapy as a tool to achieve immunomodulation in septic acute kidney injury have been proposed. The hypothesis is based on the possibility to remove inflammatory mediators and oxidants in a wide spectrum of molecular weights, thanks to new, highly permeable synthetic membranes. A new polysulfone hemofilter with high permeability and a sharp high cut-off membrane (CUREFLO™; Asahi Kasei Kuraray Medical Co., Ltd., Tokyo, Japan) has been evaluated in this study to assess IL-6 and advanced oxidation protein product removal in critically ill patients undergoing continuous renal replacement therapy. Unit performance, sieving coefficients and clearances were evaluated in fourteen patients undergoing continuous veno-venous hemofiltration and continuous veno-venous hemodialysis.Copyright © 2011 S. Karger AG, Basel.

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