• Joel L Cohen, Alexander Rivkin, Steven Dayan, Ava Shamban, W Philip Werschler, Craig F Teller, Michael S Kaminer, Jonathan M Sykes, Susan H Weinkle, and Julie K Garcia.
• Department of Dermatology, University of California, Irvine, CA.
• Aesthet Surg J. 2021 Mar 5.

BackgroundA global approach to facial rejuvenation involves multiple treatment modalities.ObjectivesThis study evaluated the impact of multimodal facial aesthetic treatment on self-reported psychological and social outcomes.MethodsHARMONY, a prospective, multicenter, 4-month study, enrolled patients aged 35 to 65 years to receive on-label treatment with a combination of hyaluronic fillers (VYC-20L, HYC-24L, and/or HYC-24L+), onabotulinumtoxinA, and bimatoprost. Fillers were injected on day 1, with touch-ups performed on day 14. OnabotulinumtoxinA was injected at month 3 into glabellar lines and/or crow's feet lines. Patients applied bimatoprost to eyelashes once daily for 17 weeks. Mean change from baseline on FACE-Q Psychological Well-being and Social Confidence Scales, FACE-Q Aging Appearance Appraisal Scale, and FACE-Q Age Appraisal Visual Analog Scale were assessed.ResultsOf 100 patients treated, 93 were evaluated at 4 months posttreatment. Significant improvement vs baseline was observed on the FACE-Q Scales for Psychological Well-being (mean change, -19.9; p < 0.00001), Social Confidence (mean change, -18.2; p < 0.00001), and Aging Appearance (mean change, -28.5; p < 0.0001). On average, patients' self-assessed age was 0.1 year older than actual age at baseline and 4.5 years younger at month 4 (p < 0.001 vs baseline). Forty-two patients experienced adverse events, all mild to moderate.ConclusionsMultimodal, full facial aesthetic treatment improves patients' self-reported psychological well-being, social confidence, aging appearance, and perceptions of chronologic age.© 2021 The Aesthetic Society.

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