• Future oncology · Jan 2015

    Review Meta Analysis

    Risk of hematological toxicities in patients with solid tumors treated with ramucirumab: a meta-analysis.

    • Omar Abdel-Rahman and Hesham ElHalawani.
    • Clinical Oncology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
    • Future Oncol. 2015 Jan 1; 11 (21): 2949-61.

    BackgroundWe performed a meta-analysis of the risk of hematological adverse events associated with ramucirumab.MethodsEligible studies included randomized Phase II and III trials of patients with solid tumors on ramucirumab, describing events of anemia, leucopenia, neutropenia, febrile neutropenia and thrombocytopenia.ResultsA total of 11 clinical trials were considered eligible for the meta-analysis. The relative risks of all-grade anemia, leucopenia, neutropenia, febrile neutropenia and thrombocytopenia were 0.88 (95% CI: 0.80-0.96; p = 0.007), 1.13 (95% CI: 0.85-1.49; p = 0.41), 1.25 (95% CI: 1.08-1.44; p = 0.002), 1.63 (95% CI: 1.30-2.06; p < 0.0001), 1.91 (95% CI: 1.52-2.42; p < 0.00001), respectively.ConclusionOur meta-analysis has demonstrated an increased risk of febrile neutropenia, all-grade and high-grade neutropenia and thrombocytopenia with ramucirumab-based treatment compared with control.

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