• Amit Chopra, Hau C Chieng, Adam Austin, Anupama Tiwari, Swati Mehta, Amit Nautiyal, Ali Hani Al-Tarbsheh, Esha Jain, Paul J Feustel, Boris Shkolnik, and Ariel Jaitovich.
• Department of Medicine, Pulmonary and Critical Care Medicine, Albany Medical Center, Albany, NY.
• Crit Care Explor. 2020 Jun 1; 2 (6): e0143.

ObjectivesTo compare the clinical outcome of mechanically ventilated patients with severe acute respiratory syndrome coronavirus 2-related acute respiratory distress syndrome, who received corticosteroid with those who did not.DesignRetrospective analysis.SettingIntensive care setting.PatientsAll adult mechanically ventilated patients, who were admitted to the ICU between March 20, 2020, and May 10, 2020, for severe acute respiratory syndrome coronavirus 2-related acute respiratory distress syndrome.InterventionsNone.Measurements And Main ResultsCohort was divided into two groups based on corticosteroid administration. The primary outcome variable was ventilator-free days at day 28. Secondary outcome variable was ICU-free days at day 30, and hospital-free days at day 30. Consecutive 61 mechanically ventilated patients with severe acute respiratory syndrome coronavirus 2-related acute respiratory distress syndrome were analyzed. Patient in corticosteroid group as compared with noncorticosteroid group have higher 28-day ventilator-free days (mean, 10.2; median, 7 [interquartile range, 0-22.3] vs mean, 4.7; median, 0 [interquartile range, 0-11]; p = 0.01).There was no significant difference noted in secondary outcomes (ICU-free days at day 30 and hospital-free days at day 30).ConclusionsAmong mechanically ventilated severe acute respiratory syndrome coronavirus 2-related acute respiratory distress syndrome patients, corticosteroids use was associated with significant improvement in 28-day ventilator-free days at day 28, but no significant improvement in ICU-free days at day 30, and hospital-free days at day 30.Copyright © 2020 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine.

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