• J Magn Reson Imaging · Feb 2006

    Diffusion-weighted imaging of normal and malignant prostate tissue at 3.0T.

    • Martin D Pickles, Peter Gibbs, Muthyala Sreenivas, and Lindsay W Turnbull.
    • Centre for Magnetic Resonance Investigations, Division of Cancer, Postgraduate Medical School, University of Hull, Hull, UK. m.d.pickles@medschool.hull.ac.uk
    • J Magn Reson Imaging. 2006 Feb 1; 23 (2): 130-4.

    PurposeTo measure the apparent diffusion coefficient (ADC) of normal and malignant prostate tissue at 3.0T using a phased-array coil and parallel imaging, and determine the utility of ADC values in differentiating tumor from normal peripheral zone (PZ).Materials And MethodsADC values were calculated for 49 patients (tumor and PZ) with evidence of prostate cancer. Additionally, for nine asymptomatic volunteers, ADC values were determined for apparently normal central gland and PZ. A single-shot EPI diffusion-weighted imaging (DWI) technique with b = 0 and 500 seconds/mm2 was employed.ResultsADC values were significantly lower for tumor (1.38 +/- 0.32 x 10(-3) mm2/second) than for patient PZ (1.95 +/- 0.50 x 10(-3) mm2/second, P < 0.001) and volunteer PZ (1.60 +/- 0.25 x 10(-3) mm2/second, P = 0.031). A considerable overlap of ADC values was noted between patient tissue types.ConclusionDWI of the prostate at 3.0T in conjunction with a phased-array coil and parallel imaging allows ADC calculation of the prostate. ADC values were lower for tumors compared to normal-appearing PZ; however, there was considerable intersubject variability.(c) 2005 Wiley-Liss, Inc.

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