• Biochem. Biophys. Res. Commun. · May 2016

    DHX33 expression is increased in hepatocellular carcinoma and indicates poor prognosis.

    • Qiu-Hong Tian, Mei-Fang Zhang, Rong-Guang Luo, Jia Fu, Cong He, Gang Hu, and Jing-Sheng Zeng.
    • Department of Oncology, First Affiliated Hospital of NanChang University, NanChang, Jiangxi 330006, China.
    • Biochem. Biophys. Res. Commun. 2016 May 13; 473 (4): 1163-1169.

    AbstractDEAH-box helicase 33 (DHX33) has been implicated in ribosome biogenesis, mRNA translation and inflammation. However, the role of DHX33 in human cancer is rarely studied. Here, we showed that DHX33 expression was significantly increased in hepatocellular carcinoma (HCC), compared with the adjacent nontumorous tissues. In a cohort of 520 patients, DHX33 expression in HCC was closely associated with tumor size (P = 0.007), serum AFP level (P = 0.011), and tumor capsule (P = 0.030). Kaplan-Meier analysis indicated high DHX33 expression was correlated with worse overall and disease-free survival, and higher recurrence rate. The prognostic value of DHX33 was further confirmed by stratified survival analysis. Multivariate analysis revealed DHX33 as an independent prognostic factor for poor overall survival (Hazard Ratio = 1.772, 95% confident interval: 1.451-2.165, P < 0.0001). Our data therefore suggest DHX33 is overexpressed in HCC and serves as a promising prognostic biomarker for this deadly disease.Copyright © 2016 Elsevier Inc. All rights reserved.

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