• Laetitia Mwilambwe-Tshilobo, Tian Ge, Minqi Chong, Michael A Ferguson, Bratislav Misic, Anthony L Burrow, Richard M Leahy, and R Nathan Spreng.
• Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.
• Soc Cogn Affect Neurosci. 2019 May 17; 14 (4): 423-433.

AbstractSocial relationships imbue life with meaning, whereas loneliness diminishes one's sense of meaning in life. Yet the extent of interdependence between these psychological constructs remains poorly understood. We took a multivariate network approach to examine resting-state fMRI functional connectivity's association with loneliness and meaning in a large cohort of adults (N = 942). Loneliness and meaning in life were negatively correlated with one another. In their relationship with individually parcelled whole-brain measures of functional connectivity, a significant and reliable pattern was observed. Greater loneliness was associated with dense, and less modular, connections between default, frontoparietal, attention and perceptual networks. A greater sense of life meaning was associated with increased, and more modular, connectivity between default and limbic networks. Low loneliness was associated with more modular brain connectivity, and lower life meaning was associated with higher between-network connectivity. These findings advance our understanding of loneliness and life meaning as distinct, yet interdependent, features of sociality. The results highlight a potential role of the default network as a central hub, providing a putative neural mechanism for shifting between feelings of isolation and purpose.© The Author(s) 2019. Published by Oxford University Press.

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