• Int. J. Radiat. Oncol. Biol. Phys. · Nov 2010

    Late rectal toxicity on RTOG 94-06: analysis using a mixture Lyman model.

    • Susan L Tucker, Lei Dong, Walter R Bosch, Jeff Michalski, Kathryn Winter, Radhe Mohan, James A Purdy, Deborah Kuban, Andrew K Lee, M Rex Cheung, Howard D Thames, and James D Cox.
    • Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77230-1402, USA. sltucker@mdanderson.org
    • Int. J. Radiat. Oncol. Biol. Phys. 2010 Nov 15; 78 (4): 1253-60.

    PurposeTo estimate the parameters of the Lyman normal-tissue complication probability model using censored time-to-event data for Grade ≥2 late rectal toxicity among patients treated on Radiation Therapy Oncology Group 94-06, a dose-escalation trial designed to determine the maximum tolerated dose for three-dimensional conformal radiotherapy of prostate cancer.Methods And MaterialsThe Lyman normal-tissue complication probability model was fitted to data from 1,010 of the 1,084 patients accrued on Radiation Therapy Oncology Group 94-06 using an approach that accounts for censored observations. Separate fits were obtained using dose-volume histograms for whole rectum and dose-wall histograms for rectal wall.ResultsWith a median follow-up of 7.2 years, the crude incidence of Grade ≥2 late rectal toxicity was 15% (n = 148). The parameters of the Lyman model fitted to dose-volume histograms data, with 95% profile-likelihood confidence intervals, were TD(50) = 79.1 Gy (75.3 Gy, 84.3 Gy), m = 0.146 (0.107, 0.225), and n = 0.077 (0.041, 0.156). The fit based on dose-wall histogram data was not significantly different. Patients with cardiovascular disease had a significantly higher incidence of late rectal toxicity (p = 0.015), corresponding to a dose-modifying factor of 5.3%. No significant association with late rectal toxicity was found for diabetes, hypertension, rectal volume, rectal length, neoadjuvant hormone therapy, or prescribed dose per fraction (1.8 Gy vs. 2 Gy).ConclusionsThese results, based on a large cohort of patients from a multi-institutional trial, are expected to be widely representative of the ability of the Lyman model to describe the long-term risk of Grade ≥2 late rectal toxicity after three-dimensional conformal radiotherapy of prostate cancer.Copyright © 2010 Elsevier Inc. All rights reserved.

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