• Hospital practice (1995) · Feb 2012

    Review

    Clostridium difficile colitis: a review.

    • Varsha Moudgal and Jack D Sobel.
    • Director, Infectious Diseases Fellowship Program, St. Joseph Mercy Hospital, Ann Arbor, MI 48106, USA. moudgalv@trinity-health.org
    • Hosp Pract (1995). 2012 Feb 1; 40 (1): 139-48.

    AbstractClostridium difficile has become an increasingly important nosocomial pathogen and is one of the most common causes of hospital-acquired diarrhea. The incidence of C difficile infection (CDI) is increasing worldwide. Overuse of antibiotics is felt to be a major contributing factor leading to the increased incidence of CDI. The clinical manifestations of CDI vary from a mild form of the disease to fulminant diarrhea, leading to significant patient morbidity and mortality. The increasing incidence of CDI has a major impact on increasing health care costs. This article will summarize the epidemiology, pathogenesis, clinical manifestations, laboratory diagnosis, and treatment options for CDI, as well as infection-control measures for the prevention of CDI.

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