• J Magn Reson Imaging · Oct 2019

    Repeatability and reproducibility of 3D MR fingerprinting relaxometry measurements in normal breast tissue.

    • Ananya Panda, Yong Chen, Kathleen Ropella-Panagis, Satyam Ghodasara, Marcie Stopchinski, Nicole Seyfried, Katherine Wright, Nicole Seiberlich, Mark Griswold, and Vikas Gulani.
    • Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
    • J Magn Reson Imaging. 2019 Oct 1; 50 (4): 1133-1143.

    BackgroundThe 3D breast magnetic resonance fingerprinting (MRF) technique enables T1 and T2 mapping in breast tissues. Combined repeatability and reproducibility studies on breast T1 and T2 relaxometry are lacking.PurposeTo assess test-retest and two-visit repeatability and interscanner reproducibility of the 3D breast MRF technique in a single-institution setting.Study TypeProspective.SubjectsEighteen women (median age 29 years, range, 22-33 years) underwent Visit 1 scans on scanner 1. Ten of these women underwent test-retest scan repositioning after a 10-minute interval. Thirteen women had Visit 2 scans within 7-15 days in same menstrual cycle. The remaining five women had Visit 2 scans in the same menstrual phase in next menstrual cycle. Five women were also scanned on scanner 2 at both visits for interscanner reproducibility.Field Strength/SequenceTwo 3T MR scanners with the 3D breast MRF technique.AssessmentT1 and T2 MRF maps of both breasts.Statistical TestsMean T1 and T2 values for normal fibroglandular tissues were quantified at all scans. For variability, between and within-subjects coefficients of variation (bCV and wCV, respectively) were assessed. Repeatability was assessed with Bland-Altman analysis and coefficient of repeatability (CR). Reproducibility was assessed with interscanner coefficient of variation (CoV) and Wilcoxon signed-rank test.ResultsThe bCV at test-retest scans was 9-12% for T1 , 7-17% for T2 , wCV was <4% for T1 , and <7% for T2 . For two visits in same menstrual cycle, bCV was 10-15% for T1 , 13-17% for T2 , wCV was <7% for T1 and <5% for T2 . For two visits in the same menstrual phase, bCV was 6-14% for T1 , 15-18% for T2 , wCV was <7% for T1 , and <9% for T2 . For test-retest scans, CR for T1 and T2 were 130 msec and 11 msec. For two visit scans, CR was <290 msec for T1 and 10-14 msec for T2 . Interscanner CoV was 3.3-3.6% for T1 and 5.1-6.6% for T2 , with no differences between interscanner measurements (P = 1.00 for T1 , P = 0.344 for T2 ).Data Conclusion3D breast MRF measurements are repeatable across scan timings and scanners and may be useful in clinical applications in breast imaging.Level Of Evidence2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;50:1133-1143.© 2019 International Society for Magnetic Resonance in Medicine.

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