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- Yuji Takahashi, Kouichi Hashimoto, and Shoji Tsuji.
- Department of Neurology, Toshiba Hospital, Tokyo, Japan. TAKAHASHIY-INT@h.u-tokyo.ac.jp
- J Pain. 2004 Apr 1; 5 (3): 192-4.
UnlabelledWe present 2 patients with severe and intractable central poststroke pain (CPSP) after right posterolateral thalamic infarcts who were successfully treated with zonisamide. The mechanism of action was presumed to be the suppression of overacting thalamic relay neurons by blockade of low voltage-activated calcium channel or by increasing gamma-aminobutyric acid (GABA) release. Zonisamide can be one of the therapeutic options for severe CPSP and might provide an insight into the pathogenesis of CPSP.PerspectiveThe blockade of T-type VGCC or the increase in GABA release caused by zonisamide presumably suppresses abnormal activities of thalamic sensory neurons.Copyright 2004 American Pain Society
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