• Yuxuan Lu, Haiqiang Jin, Yuhua Zhao, Yuxian Li, Jun Xu, Jiayu Tian, Xiaoting Luan, Siwei Chen, Wei Sun, Shouzi Zhang, Shunliang Xu, Feiqi Zhu, Luzeng Chen, Dunzhu Mima, Yongan Sun, and Cidan Zhuoga.
• Department of Neurology, Peking University First Hospital, Beijing, China.
• Neurocrit Care. 2022 Apr 1; 36 (2): 395-403.

BackgroundStudies of the impact of increased hemoglobin on spontaneous intracerebral hemorrhage (ICH) are limited. The present study aimed to explore the effect of increased hemoglobin on ICH.MethodsA retrospective single-center study using medical records from a database processed by univariate and multivariate analyses was performed in the People's Hospital of Tibet Autonomous Region in Lhasa, Tibet, China.ResultsThe mean hemoglobin level in 211 patients with ICH was 165.03 ± 34.12 g/l, and a median hematoma volume was 18.5 ml. Eighty-eight (41.7%) patients had large hematomas (supratentorial hematoma ≥ 30 ml; infratentorial hematoma ≥ 10 ml). No differences in ICH risk factors between the groups with different hemoglobin levels were detected. Increased hemoglobin was independently associated with large hematomas [odds ratio (OR) 1.013, P = 0.023]. Increased hemoglobin was independently associated with ICH with subarachnoid hemorrhage (OR 1.014, P = 0.016), which was more pronounced in men (OR 1.027, P = 0.002). Increased hemoglobin was independently associated with basal ganglia hemorrhage and lobar hemorrhage in men (OR 0.986, P = 0.022; OR 1.013, P = 0.044, respectively) but not in women (P > 0.1).ConclusionsIncreased hemoglobin was independently associated with large hemorrhage volume. Increased hemoglobin was independently associated with lobar hemorrhage in men and ICH with subarachnoid hemorrhage, which was more pronounced in men. Additional studies are needed to confirm our findings and explore potential mechanisms.© 2021. The Author(s).

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