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Ann Acad Med Singap · Mar 2000
Case ReportsA case report of Aspergillus hypersensitivity syndrome with obstructing bronchial aspergillosis.
- P Lee, S K Goh, W M Yap, and C C Chan.
- Department of Respiratory Medicine, Tan Tock Seng Hospital, Singapore.
- Ann Acad Med Singap. 2000 Mar 1; 29 (2): 246-8.
IntroductionA 62-year-old Indian male with diabetes mellitus presented with atypical, overlap features of Aspergillus hypersensitivity syndrome and obstructing bronchial aspergillosis.Clinical PictureHe was febrile and tachypnoeic with diffuse crepitations and wheezing. Chest X-ray was normal but eosinophil count was 2900/mm3 and Ig E > 10,000 IU/ml.Treatment And OutcomeHe responded initially to high dose steroid therapy but deteriorated subsequently from extensive mucus plugging of the bronchial tree which resulted in respiratory failure and death. He was HIV-negative.ConclusionCulture and histologic examination of bronchoscopically identified tracheobronchial mucus plugs should be performed as early treatment may be life-saving.
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