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Southern medical journal · Jun 1996
Case ReportsPersistent paralysis after prolonged use of atracurium in the absence of corticosteroids.
- E R Rubio and C B Seelig.
- Coastal Area Health Education Center, New Hanover Regional Medical Center, Wilmington, NC, USA.
- South. Med. J. 1996 Jun 1;89(6):624-6.
AbstractNeuromuscular blocking agents (NMBAs) are often used for patients requiring prolonged mechanical ventilation. Reports of persistent paralysis after the discontinuance of these drugs have most often involved aminosteroid-based NMBAs such as vecuronium bromide, especially when used in conjunction with corticosteroids. Atracurium besylate, a short-acting benzylisoquinolinium NMBA that is eliminated independently of renal or hepatic function, has also been associated with persistent paralysis, but only when used with corticosteroids. We report a case of atracurium-related paralysis persisting for approximately 50 hours in a patient who was not treated with corticosteroids.
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