• R Geyer, M Levy, M S Berger, J Milstein, B Griffin, and W A Bleyer.
• Department of Pediatrics, Children's Hospital and Medical Center, University of Washington, Seattle.
• Neurosurgery. 1991 Nov 1; 29 (5): 707-10; discussion 710-1.

AbstractAlthough the prognoses of children with medulloblastoma have improved dramatically over the last several decades, the reported survival for very young children with this tumor remains poor. We undertook a retrospective review of patients less than 36 months of age at the time of the diagnosis of a medulloblastoma who were treated at our institution during a 36-year period. Of 28 such patients, 10 patients are presently surviving without disease at a median of 150 months from diagnosis. The presence of a metastatic tumor at the time of diagnosis was identified as a significant indicator of a poor prognosis, and all completely staged patients without metastasis are surviving without a recurrence of disease. This report suggests that the survival of very young children with a medulloblastoma may not be as poor as has been previously reported, particularly if a disseminated tumor is not present at the time of diagnosis.

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