• Curr Top Med Chem · Jan 2020

    Novel Drugs Targeting the SARS-CoV-2/COVID-19 Machinery.

    • Ariane Sternberg, Dwight L McKee, and Cord Naujokat.
    • Center and Network for Targeted Oncology, Muehlackerweg 8, D-69239 Heidelberg, Germany.
    • Curr Top Med Chem. 2020 Jan 1; 20 (16): 1423-1433.

    AbstractLike other human pathogenic viruses, coronavirus SARS-CoV-2 employs sophisticated macromolecular machines for viral host cell entry, genome replication and protein processing. Such machinery encompasses SARS-CoV-2 envelope spike (S) glycoprotein required for host cell entry by binding to the ACE2 receptor, viral RNA-dependent RNA polymerase (RdRp) and 3-chymotrypsin-like main protease (3Clpro/Mpro). Under the pressure of the accelerating COVID-19 pandemic caused by the outbreak of SARS-CoV-2 in Wuhan, China in December 2019, novel and repurposed drugs were recently designed and identified for targeting the SARS-CoV-2 reproduction machinery, with the aim to limit the spread of SARS-CoV-2 and morbidity and mortality due to the COVID-19 pandemic.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

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