• Yue Suo, Weiqi Chen, Yuesong Pan, Yujing Peng, Hongyi Yan, Wei Li, Gaifen Liu, and Yongjun Wang.
• Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Center for Neurological Diseases, Beijing, China; Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China; Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China.
• J Stroke Cerebrovasc Dis. 2018 Jul 1; 27 (7): 2006-2013.

BackgroundHematoma expansion is an independent risk factor of unfavorable outcome after intracerebral hemorrhage (ICH), which always occurs in the early phase after symptoms onset. The relationship between underlying small vessel disease (SVD) and hematoma expansion was inconsistent in patients with ICH. We aimed to investigate the relationship between magnetic resonance (MR) characteristics of SVD and hematoma expansion in patients with ICH within 72 hours after symptoms onset.MethodsData were derived from a cohort of biological sample collection from April 2014 to April 2016. We recruited patients aged 18 years or older with a baseline and follow-up computed tomography within 72 hours after symptom onset, as well as an MR imaging within 3 months before or after ICH. Hematoma expansion was defined as an increase in volume between baseline and final hematoma volume exceeding 6 mL or 33% of the baseline volume. Multivariate logistic regression was used to explore the association between clinical characteristics, imaging markers, total SVD score, and hematoma expansion in patients with ICH.ResultsA total of 103 patients experienced hematoma expansion among the 263 enrolled patients (mean age 53.4 ± 14.0 years, 76.4% male). Electrocardiogram abnormal rhythm, fewer non-lobar microbleeds, lower plasma homocysteine concentration, and smaller baseline hematoma volume independently predicted the risk of hematoma expansion (P = .004, .021, .001, and .024, respectively). Odds ratios ranged from 1.02 to 3.72.ConclusionsOur study suggested that the use of MR markers revealing underlying SVD may help to identify patients with ICH with potential hematoma expansion.Copyright © 2018 National Stroke Association. Published by Elsevier Inc. All rights reserved.

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