• Andrzej Wykretowicz, Agata Schneider, Tomasz Krauze, Adam Szczepanik, Agnieszka Banaszak, Andrzej Minczykowski, Jaroslaw Piskorski, and Przemyslaw Guzik.
• Department of Cardiology-Intensive Therapy, Poznan University of Medical Sciences, Poznan, Poland.
• Eur. J. Clin. Invest. 2019 Aug 1; 49 (8): e13131.

BackgroundNew index of pulse wave velocity to global longitudinal peak systolic strain (PWV/GLPSS) was reported to be associated with cardiovascular damage. We evaluated the prognostic role of this metric in survivors of acute myocardial infarction (AMI).Material And MethodsWe investigated in 569 patients with AMI, whether PWV/GLPSS was associated with a composite endpoint of death, stroke or new myocardial infarction, in long-term follow-up. Left ventricular longitudinal strain was evaluated by speckle tracking, and carotid arterial stiffness (local PWV) was determined using radiofrequency data technology.ResultsDuring follow-up (median 1316 days), 114 subjects reached composite endpoint. These subjects were significantly older (P < 0.0001) and were characterized by lower ejection fraction (P < 0.0001), lower GLPSS (P < 0.0001), higher PWV (P = 0.007) and lower PWV/GLPSS index (P < 0.0001). Patients with PWV/GLPSS <-0.74 were at a significantly higher risk for the composite endpoint during the follow-up (hazard rate: 1.7; 95% confidence interval: 1.2-2.6; P < 0.001). The PWV/GLPSS was additive to the predictive value of EF < 35%-patients with PWV/GLPSS <-0.74 and EF < 35% had the highest risk for the endpoint events.ConclusionsThe current study shows that PWV/GLPSS index has significant, independent and additive value in predicting CV complications, in subjects with myocardial infarction.© 2019 Stichting European Society for Clinical Investigation Journal Foundation.

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